Spirochete Borrelia and Lyme disease

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Epidemiology:

  • The village of Lyme in Connecticut (US) became famous in 1977 after an epidemic of arthritis broke out among the village's children and adults
  • In 1982, the gram negative sprirochete was identified by Willy Burgdorfer
  • WHO figures show explosive increase in Lyme disease.
  • More and more borrelia species found. Spread 16 different diseases
  • Age-related: peak ages between 5 - 15 years and between 40 - 55 years
  • Peak months: June and July
  • Susceptibility to chronification: fatigue already present before tick bite
  • Also of importance quality gut flora present, environmental factors, co-morbilities and lifestyle.

Which spirochetes cause Lyme disease?

  • Borrelia borreliosis
  • B. Burdorferi Arthritis
  • B. Afzelli Skin disease
  • B. Garinii Neuroinflammation

Interaction between hosts and borrelia bacteria

Most pathogen infections initiate a classical IS immune response based on chelation of iron. Borrelia has bypassed this strategy via the use of manganese as its main "survival" metal.

Borrelia uses zinc and manganese to profile and protect against oxidative stress.

This strategy leads to formation of IL 10 and immune suppressive status.

Not everyone is susceptible to Lyme disease.

Risk factors include:

  • Lifestyle
  • Age and gender
  • Vitamin intake
  • Vitamin and mineral status = deficiencies present
  • Smoking
  • Present Low grade inflammation (LGI)
  • Present insulin, leptin and cytokine resistance
  • Eating mammalian products by Neu5gc present

Borrelia can:

  • Inducing production of IL 10 via STAT 3
  • Chasing manganese and zinc 
  • Encouraging SOC 1 / 3
  • Complementary system brakes
  • Changing metabolism of immune system
  • Phospholipid (especially choline) stems
  • COX-2 and LOX-5 inhibitors

Virulence of Borrelia:

  • Damage via immune system.
  • He leaves a harmful reaction due to the wound he causes with his "drill". 
  • It is not itself basally responsible for the immune response.
  • It does not possess genes responsible for producing nucleotides, amino acids, fatty acids and enzyme co-factors. These he consumes from us.
  • By he activation of our body's own proteases caused, breakdown of connective tissue barriers can occur, further infiltration of joints, infiltration of heart muscle, breakdown of blood-brain barrier. Algae inhibit the proteases activated or endogenously produced by borrelia.

Spirochete has a unique shape with its long and not round, more the shape of a drill or screw. It has no LPS, hardly any lipoproteins, flagella on the inside (invisible), no toxin production, so not or hardly immunogenic. It does not cause damage by toxins but by invasion. Its action in the body is to protect itself, it does not want to be killed.

Its speed makes it "unhuntable". 6% of the total genome is related to mobility = movement. Like a formula one car. 0.28 cm/minute = 2x as fast as the fastest neutrophil. ('n immune cell) 

Inhibition of Borrelia is essential to master the disease. Make the bacteria heavy so that the immune system can access it.

If the bacterium slows down, neutrophils can kill it. 

Many blood tests are negative, as borrelia moves better in viscous tissue and is thus not present in the blood.

Blood tests are certainly not reliable in Post-Tratment Lyme Disease Syndrom (PTLS).

There is doubt about whether or not the bacteria are present in patients still suffering from borreliosis symptoms

The use of clinical trial is imperative.

Treatments

Goal of the approach for adequate treatment, should aim to counter-regulate the strategies by which borrelia evades the immune system as soon as possible. Those that cannot do so are susceptible to Lyme disease. Of course, this is also where a person's history and lifestyle plays a role.

 Treatment, regular:

  • In acute phase, within 2 weeks of the bite, antibiotics 5 to 28 days, depending on type of borrelia and antibiotics. This slows down the bacteria and when a person then has an alert working immune system, he is able to ward off the spirochete. Alert immune system? This is where a person's history does matter enormously.
  • Not recommended interventions in Lyme borreliosis or PTLDS:
    • Long-term antibiotic use
    • Repeated antibiotic course for same infection
    • Combinations of antibiotic cures
    • Alternating dosing of antibiotics, few days yes alternating with few days no.
    • Cephalosporins, such as cephalexin, benzathine pinicillin G, fluoroquinolones, carbapenems, vancomycin, metronidazole, tinidazole, trimethoptimsulfamethoxazole, amantadine, isoniazid, rifampin or fluconazole
    • Medications against Babesiosis (malaria-like parasite) or against Bartonella infection without evidence of active infection
    • Ozone therapy, oxygen bars
    • Herbs, such as burnt mugwort or gluthathione
    • Chelation and heavy metal therapy
    • Intravenous immunoglobulin
    • Stem cell therapy
    • Medications (such as cholestyramine), enemas, bee venom, various hormone therapies(such as thyroid hormone), lithium orotate, naltrexone or bleach (think also chlorine in drnwater here)

Integral treatment of Lyme disease

Aimed at slowing down the spirochete and making its environment unpleasant.

His weakness:

  • It has no synthesis capacity of its own for amino acids, nucleotides and fat.
  • 100% carbohydrate-dependent
  • Manganese dependent 
  • ph sensitive
  • rest sensitive

Here are some tips. Do remember to pick these up with a PNI - therapist, as it is very important to get a good understanding of which tips and in what dosage are relevant to you and why!

Anti-Borrelia agents:

Olive oil and coconut oil

Scutellaria baicalensis

Oregano oil: strongest anti - bacterial activity

Lactoferrin in high dose. Lactoferrin is toxic to borrelia bacteria. In addition, it captures the free iron released as a result of tissue damage by the "drill" of spirochete. Free iron in turn is a risk factor for profiling any other pathogens and carcinogenic cells present.

High dose of resveratrol, normal dose of berberine

Cholesterol from the sea: Squalene necessary, further eating algae, marine animals and fish MSC to make the beast so heavy and sluggish. You can also consider Perilla seed oil, amaranth oil.

Borrelia's metabolism is 100% dependent on carbohydrates. This is a weakness of the spirochete that we can use. Diet should be ketogenic in calories, but not in volume! Omega 3 supplementation.

High dose of zinc as natural antagonist of manganese in borrelia bacteria.

Furthermore, a good multi vitamin and a multi mineral

Most symptoms are caused by the immune system itself. For this, use curcuma and green tea in your diet.

Vitamin D = direct defence by innate immune system. If vitamin D is low, supplement it for anti-inflammatory benefits.

NAC, breaks down biofilms. There are no studies yet on the action of NAC in borreliosis, but recommended.

Breathing exercise: hypercapnia 5 to 8x 2 minutes a day.

Using nutrition as medicine.

As mentioned earlier, as a practitioner, you will also have to include your history in the approach. After all, it determines your immune response and disease course and recovery.

Have you contracted borrelia bacteria? Request a consultation. This can be done live or online.